Sphingosine Kinase 1 (SphK1) overexpression contributes to cetuximab resistance in human colorectal cancer models
نویسندگان
چکیده
Dipartimenti di Endocrinologia ed Oncologia Molecolare e Clinica; Scienze Biomorfologiche e Funzionali, Università di Napoli “Federico II”, Naples, Italy; Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università di Roma "Tor Vergata", Rome, Italy; Institute of Biostructures and Bioimages, National Research Council, Naples, Italy; CEINGE, Biotecnologie Avanzate, Naples, Italy; Dipartimento di Biologia e Patologia Cellulare e Molecolare "L.
منابع مشابه
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models.
PURPOSE Although the anti-EGF receptor (EGFR) monoclonal antibody cetuximab is an effective strategy in colorectal cancer therapy, its clinical use is limited by intrinsic or acquired resistance. Alterations in the "sphingolipid rheostat"-the balance between the proapoptotic molecule ceramide and the mitogenic factor sphingosine-1-phosphate (S1P)-due to sphingosine kinase 1 (SphK1) overactivati...
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Sphingosine kinase 1 (Sphk1) is a highly conserved lipid kinase that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P). Growing studies have demonstrated that Sphk1 is overexpressed in various types of solid cancers and can be induced by growth factors, cytokines, and carcinogens, leading to the increase of S1P production. Subsequently, the increased Sphk1/S1P facilitates cancer ...
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OBJECTIVE As a better understanding of the molecular basis of carcinogenesis has emerged, oncogene-specific cell-signaling pathways have been successfully targeted to treat human malignances. Despite impressive advances in oncogene-directed therapeutics, genetic instability in cancer cells often manifest acquired resistance. This is particularly noted in the use of tyrosine kinase inhibitors th...
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